. To obtain accurate spatial information on cancer distribution with a novel prostate biopsy regimen.
Methods. From 2003 to 2005, 265 patients underwent a three fan-shaped biopsy (3FSB) technique of 12 to 14
cores and sextant biopsy (SB) simultaneously. When both techniques had positive findings, and radical prostatectomy
was performed, the concordance among the positive biopsy locations of the SB, 3FSB, and the
combination of both (the reference standard biopsy [RSB]), the proven locations of cancer, and the presence of
extracapsular extension and positive surgical margins was calculated.
. A total of 41 patients were selected, and 74 locations (left and right apex, left and right lobe) had
cancer.Of these, 61 were confirmed by RSB, 58 by 3FSB, and 43 by SB with a sensitivity of 95%, 78%, and 58%,
respectively. The sensitivity at the apical location was consistently greater for the 3FSB at 68% (19 of 28)
compared with 40% (11 of 28) for all proven apical positive localizations and 100% (19 of 19) compared with
58% (11 of 19) for the RSB. The receiver operating characteristic analysis showed 78% accuracy for 3FSB and
68% accuracy for SB compared with the RSB. At the apex, the 3FSB and SB revealed positive surgical margins
with a sensitivity of 1 and 0.4, specificity of 0.067 and 0.4, positive predictive value of 0.263 and 0.182, and
negative predictive value of 1 and 0.667, respectively.
. The 3FSB had a great ability to find cancer in the gland, especially at the apex.
UROLOGY 68: 1301–1304, 2006. © 2006 Elsevier Inc.href="http://www.uropro.it/pubblicazioni/can-biopsy-be-a-reliable-predictor-of-spatial-distribution-of-prostate-cancer-comparison-of-a-novel-biopsy-regimen-with-radical-prostatectomy-findings.pdf">clicca qui per leggere la versione completa in PDF