Pubblicazioni scientifiche

Long-term PSA-free survival and castration-free survival with delayed antiandrogen therapy in patients with one versus two or more positive nodes at prostatectomy

Purpose To analyze time in relation to biochemical recurrence (BCR) and antiandrogen therapy (ADT) in patients with node metastasis at retropubic prostatectomy (RRP) and to identify prognostic factors of BCR- and ADT-free survival. Methods Positive node patients at RRP and extended pelvic lymph node dissection (ePLND) were recruited retrospectively. Neoadjuvant and adjuvant therapy were exclusion Continua a leggere

A Randomized Prospective Trial to Assess the Impact of Transurethral Resection in Narrow Band Imaging Modality on Non–Muscle-Invasive Bladder Cancer Recurrence

Background: Narrow band imaging (NBI) is an optical enhancement technology that filters white light into two bandwidths of illumination centered on 415 nm (blue) and 540 nm (green). NBI cystoscopy can increase bladder cancer (BCa) visualization and detection at the time of transurethral resection (TUR). NBI may therefore reduce subsequent relapse following TUR. Objective: Assess Continua a leggere

Predictors of Symptomatic Lymphocele After Lymph Node Excision and Radical Prostatectomy

OBJECTIVES To identify the prognostic factors of symptomatic lymphocele. METHODS From January 2004, 359 patients underwent pelvic lymph node excision during radical prostatectomy at our center, of whom, 347 were followed up for 6 months. RESULTS At a median follow-up of 14.5 months (range 6-54), 44 patients had developed a lymphocele (12.6%). In 26 patients Continua a leggere

Feasibility of Transurethral Resection of Bladder Lesion Performed Entirely by Means of Narrow-Band Imaging

Abstract Purpose: To assess the feasibility of transurethral resection (TUR) of bladder lesions performed entirely by means of a narrowband imaging (NBI) modality. Patients and Methods: Data from an ongoing prospective randomized trial (NCT01004211) were extracted. Quality outcomes of standard TUR and NBI TUR were compared. Complications were graded according to the Clavien-Dindo system. Results: Continua a leggere

New Italian guidelines on bladder cancer, based on the World Health Organization 2004 classification

OBJECTIVE To provide evidence-based recommendations on bladder cancer management METHODS A multidisciplinary guideline panel composed of urologists, medical oncologists, radiotherapists, general practitioners, radiologists, epidemiologists and methodologists conducted a structured review of previous reports, searching the Medline database from 1 January 2004 to 31 December 2008. The milestone papers published before January 2004 were accepted for Continua a leggere

Bipolar Transurethral Resection in Saline (TURis): Outcome and Complication Rates After the First 1000 Cases

Abstract Objective: TURis is an emerging technique that shows the same efficacy of monopolar resection. However, there is currently little available data on the safety of bipolar devices. We assessed outcome and safety of TURis on a large cohort of patients with at least 6 months’ follow-up. Patients and Methods: Between January 2006 and October Continua a leggere

Prognostic factors of persistently detectable PSA after radical prostatectomy

Objectives: To determine predictive factors of detectable prostate-specific antigen (PSA) in patients submitted to radical prostatectomy (RP) and to define the prognostic role of this event. Methods: A total of 318 patients who underwent RP between 2002 and 2007 were selected from our prospective database. Selection criteria were: no neo-adjuvant therapy; surgical specimens analyzed and Continua a leggere

Narrow band imaging for detecting residual/ recurrent cancerous tissue during second transurethral resection of newly diagnosed non-muscle-invasive high-grade bladder cancer

OBJECTIVE To determine if narrow-band imaging (NBI) can be used to detect high-grade cancerous lesions missed with the white light at the time of a second transurethral resection (TUR) of high-grade non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS Consecutive patients with newly diagnosed high-grade NMIBC were enrolled in a prospective observational study. Patients with incomplete Continua a leggere

Potency Preserving Cystectomy With Intrafascial Prostatectomy for High Risk Superficial Bladder Cancer

Purpose : We report the oncological and functional results of potency sparing cystectomy with intrafascial prostatectomy for high risk, superficial bladder cancer. Materials and Methods : A total of 37 patients underwent potency sparing cystectomy and orthotopic urinary substitution from 2001 to 2005. Inclusion criteria were age younger than 70 years, Charlson comorbidity index less Continua a leggere

Surgery Insight: advantages and disadvantages of laparoscopic radical cystectomy to treat invasive bladder cancer

SUMMARY Laparoscopic radical cystectomy (LRC) is a challenging technique, but it has been proposed as an alternative to open radical cystectomy (ORC), which is currently the gold standard treatment for muscle-invasive or highrisk superficial bladder cancer. So far, approximately 200 cases treated with LRC have been reported in the peer-reviewed literature, but follow-up has generally Continua a leggere

CAN BIOPSY BE A RELIABLE PREDICTOR OF SPATIAL DISTRIBUTION OF PROSTATE CANCER? COMPARISON OF A NOVEL BIOPSY REGIMEN WITH RADICAL PROSTATECTOMY FINDINGS

ABSTRACT Objectives . To obtain accurate spatial information on cancer distribution with a novel prostate biopsy regimen. Methods. From 2003 to 2005, 265 patients underwent a three fan-shaped biopsy (3FSB) technique of 12 to 14 cores and sextant biopsy (SB) simultaneously. When both techniques had positive findings, and radical prostatectomy was performed, the concordance among Continua a leggere

Role of Transurethral Resection of the Prostate and Biopsy of the Peripheral Zone in the Same Session after Repeated Negative Biopsies in the Diagnosis of Prostate Cancer

Abstract Objective: To determine the role of the transurethral resection of the prostate (TURP) together with biopsies of the peripheral zone in the diagnosis of prostate cancer after repeated negative transrectal biopsies and increasing prostate-specific antigen (PSA) levels. Methods: From 2003 to 2004, 43 patients, aged 53–69 yr, were seen for a history of at Continua a leggere

PELVIC FLOOR RECONSTRUCTION BEFORE ORTHOTOPIC BLADDER REPLACEMENT AFTER RADICAL CYSTECTOMY FOR BLADDER CANCER

ABSTRACT Female incontinence and pelvic organ prolapse have been defined as contraindications to orthotopic bladder substitution. A 75-old-year woman with slight stress incontinence, Stage III cystocele, and vaginal vault prolapse after subtotal hysterectomy underwent radical cystectomy for Stage T2 bladder cancer. After radical cystectomy, pelvic floor integrity was restored by colposacropexy with a rectangular polypropylene Continua a leggere

Laparoscopic Radical Cystectomy

Address *Urology Unit, Department of Surgical Oncology, National Institute for Cancer Research, Largo Rosanna Benzi 10, Genoa 16100, Italy. E-mail: angelo.naselli@libero.it Current Urology Reports 2005, 6:106–108 Current Science Inc. ISSN 1527-2737 Copyright © 2005 by Current Science Inc. Laparoscopic radical cystectomy is an emerging technique. It has been proposed as an alternative to open radical Continua a leggere

LongTerm Results of Excision of Small Renal Cancer Surrounded by aMinimal Layer of Grossly Normal Parenchyma: Reviewo f 94 Cases

Abstract Objective: To assess safety and effectiveness of excision of small renal cancer. Methods: We reviewed the records of 94 patients, who underwent, from 1992 to 2001, excision of renal tumor leaving around it a thin layer of grossly normal parenchyma and adjacent perinephric fat. This technique has been called enucleoresection, as it is not Continua a leggere